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At the same time, ferroptosis is accompanied by excessive ROS production, resulting in depolarization of the mitochondrial membrane potential and opening of the mitochondrial permeability transition pore (MPTP), further leading to cell rupture (Ravingerov et al., 2020)

With respect to the newness criterion, the applicant stated that a new drug application (NDA) for CYTALUX was approved by FDA on November 29, 2021, as an optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions

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cDNA was synthesized from 1 g of total DNA-free RNA using random hexamer primers and Superscript III reverse transcriptase (Life Technologies Carlsbad, CA, United State) following the manufacturer instructions